Stimulation of Igg Antibody Response in Vitro by T Cell-replacing Factor
نویسندگان
چکیده
A soluble factor (TRF) produced by mixtures of allogeneic mouse spleen, lymph node, and thymus cells functionally replaces T cells in a primary IgM antibody response to sheep blood cells in vitro. It is now shown that TRF can also reconstitute an IgG antibody response in T cell-deprived spleen cultures derived from preimmunized mice. The optimal time of addition and the amount of TRF required differ between primary and secondary in vitro systems.
منابع مشابه
Mechanism of T-cell help in the immune response to soluble protein antigens. I. Evidence for in situ generation and action of T-cell- replacing factor during the anamnestic response to dinitrophenyl keyhole limpet hemocyanin in vitro
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 137 شماره
صفحات -
تاریخ انتشار 1973